Drug delivery system. DDS of thrombolytic agents.
نویسندگان
چکیده
منابع مشابه
Development of novel drug delivery system (DDS) technologies for proteomic-based drug development.
With the success of human genome projects, the focus of life science research has shifted to the functional and structural analyses of proteins, such as disease proteomics. These structural and functional analyses of expressed proteins in the cells and/or tissues are expected to contribute to the identification of therapeutically applicable proteins for various diseases. Thus, pharmaco-proteomi...
متن کاملPreparation of pH-sensitive anionic liposomes designed for drug delivery system (DDS) application.
We prepared pH-sensitive anionic liposomes composed solely of anionic bilayer membrane components that were designed to promote efficient release of entrapped agents in response to acidic pH. The pH-sensitive anionic liposomes showed high dispersion stability at neutral pH, but the fluidity of the bilayer membrane was enhanced in an acidic environment. These liposomes were rather simple and wer...
متن کامل[Targeting mitochondria: innovation from mitochondrial drug delivery system (DDS) to mitochondrial medicine].
Mitochondrial dysfunction has been implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require the targeted delivery of therapeutic agents to mitochondria. This will likely be achieved through innovations in the areas of the nanotechnology of intracellular trafficking. Mitochondrial delivery s...
متن کاملTemperature-sensitive liposome-mediated delivery of thrombolytic agents.
BACKGROUND Clinical efficacy of thrombolytic drugs is limited by lack of specific delivery and requires large therapeutic doses which increase toxicity. Encapsulating these drugs in temperature-sensitive liposomes and applying hyperthermia to deliver thrombolytic agents locally to thrombus might theoretically favourably alter the therapeutic window. The objectives of this study were to formulat...
متن کاملPhytosome: Drug Delivery System for Polyphenolic Phytoconstituents
Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 1989
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.4.270